dasatinib will raise the amount or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
voriconazole will enhance the amount or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Bodily dependence and withdrawal reactions. VALIUM might cause physical dependence and withdrawal reactions.
Keep an eye on Carefully (one)methylphenidate transdermal will raise the level or result of diazepam by decreasing metabolism.
The system of tolerance to benzodiazepines features uncoupling of receptor web-sites, alterations in gene expression, down-regulation of receptor web-sites, and desensitisation of receptor web pages into the result of GABA. About a single-third of people who get benzodiazepines for more time than four months turn into dependent and expertise withdrawal syndrome on cessation.[20]
diazepam will raise the level or influence of midazolam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Coadministration of gentle CYP3A4 inhibitors with midazolam intranasal could trigger bigger midazolam systemic publicity, which may lengthen sedation.
Reserve concomitant prescribing of such prescription drugs in people for whom other cure selections are insufficient. Restrict dosages and durations for the minimal demanded. Watch carefully for signs of respiratory despair and sedation.
Common specifics of the Safe and sound and effective use of VALIUM. Medicines are occasionally prescribed for reasons apart from All those outlined inside of a Medication Guide. Usually do not use VALIUM for just a situation for which it wasn't prescribed.
griseofulvin will lower the level or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
diazepam will enhance the amount or influence of ruxolitinib topical by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unknown.
conivaptan will boost the amount or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Impact of coadministration of a here dual CYP3A4 and CYP2C19 inhibitor with fedratinib hasn't been researched.
醫學界視苯二氮䓬類藥物較以往常用的巴比妥鹽類藥物更好，因為後者的治療劑量和中毒劑量差距較少（即是稍微過量便容易中毒），且会形成较强的依赖性。過量服用地西泮較不容易引致死亡（不過仍然有人因服用地西泮過量而死亡），但如同時服用其它鎮靜劑或酒類則會增加危險。
lasmiditan, diazepam. Both raises effects of the opposite by sedation. Use Warning/Keep an eye on. Coadministration of lasmiditan and other CNS depressant medicine, including Alcoholic beverages have not been evaluated in medical research. Lasmiditan may possibly cause sedation, along with other cognitive and/or neuropsychiatric adverse reactions.